Prions and the like
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منابع مشابه
Prions and the like
Fatal Flaws by Jay Ingram, the Canadian author, writer and broadcaster, is the latest popular science book on transmissible spongiform encephalopathies. Unlike previous books—such as Deadly feasts by Richard Rhodes, The pathological protein by Philip Yam, Comment les vaches sont devenues folles by Maxime Schwartz, The family that couldn't sleep by Daniel Max and The collectors of lost souls by ...
متن کاملPrions and prion-like proteins.
Prions are self-replicating protein aggregates and are the primary causative factor in a number of neurological diseases in mammals. The prion protein (PrP) undergoes a conformational transformation leading to aggregation into an infectious cellular pathogen. Prion-like protein spreading and transmission of aggregates between cells have also been demonstrated for other proteins associated with ...
متن کاملThe Master Code of Biology: from Prions and Prions-like Invariants to the Self-assembly Thesis
Concretely, the dynamics of this Genomics/Proteomics coupling is appeared as two correlated curves translating topology and the dynamic evolution of a hierarchical classification of codons throughout the studied sequence. More precisely, the study of these curves shows that this tool highlights the functional areas and active sites within proteins. The specific context of Prions area could be a...
متن کاملThe Toll-Like Receptor Agonist Imiquimod Is Active against Prions
Using a yeast-based assay, a previously unsuspected antiprion activity was found for imiquimod (IQ), a potent Toll-like receptor 7 (TLR7) agonist already used for clinical applications. The antiprion activity of IQ was first detected against yeast prions [PSI (+) ] and [URE3], and then against mammalian prion both ex vivo in a cell-based assay and in vivo in a transgenic mouse model for prion d...
متن کاملPrions and Prion-Like Pathogens in Neurodegenerative Disorders
Prions are unique elements in biology, being able to transmit biological information from one organism to another in the absence of nucleic acids. They have been identified as self-replicating proteinaceous agents responsible for the onset of rare and fatal neurodegenerative disorders-known as transmissible spongiform encephalopathies, or prion diseases-which affect humans and other animal spec...
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ژورنال
عنوان ژورنال: Brain
سال: 2013
ISSN: 1460-2156,0006-8950
DOI: 10.1093/brain/awt179